L-Glycine, or glycine, is a nonessential amino acid due to the body's ability to manufacture glycine from serine. However, glycine is also taken in through a healthy diet of meat, fish, dairy and legumes. Glycine is considered the simplest amino acid in the body and has many important roles. Glycine is a neurotransmitter in the central nervous system and of major importance to the creation of protein, peptides, creatine, purines, bile salts, glycogen, hemoglobin, ATP, nucleic acids, porphyrins, glutathione, glucose, and other amino acids. Glycine is a water-soluble protein amino acid that displays anti-inflammatory, antispastic, and antipsychotic activity.
Glycine has reportedly made symptoms worse when taken with clozapine in people with schizophrenia. Although this effect has not been reported in connection to other antipsychotic drugs, it is not recommended that glycine be combined with any.
For the most part, glycine is well tolerated by most people. There have been some reported cases of side effects that include nausea, vomiting, and upper gastrointestinal tract discomfort.
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