Coenzyme Q10, or CoQ10, has many important roles within the body. It is a member of the ubiquinones family, which are water-soluble, among other characteristics. CoQ10 can be found high quantities in the human heart, liver, kidney, and pancreas. CoQ10 is present throughout the human cell, in the mitochondria, the nucleus, the microsomes, and cytosol. Good sources of CoQ10 are meats and seafood although, the body is capable of creating the nutrient. CoQ10 is involved in the production of ATP as well as in much of the antioxidant activity in the mitochondria and cell membranes. COQ10 has the abiltiy to hinder the oxidation of LDL-cholesterol. The whole CoQ10 family is largely involved with the functions of the mitochondria, such as electron transport and energy production.
CoQ10 should not be used with warfarin, as it will reduce the effectiveness. Antidiabetes drugs, antihypertensive drugs, and insulin should be used cautiously with CoQ10, as blood glucose levels, blood pressure, and blood sugar may be affected (typically decrease). Red yeast may decrease CoQ10 levels in the body while l-carnitine may work together effectively with CoQ10.
When high doses of CoQ10 are taken, side effects such as nausea, vomiting, diarrhea, loss of appetite, heartburn, and epigastric discomfort may be experienced by some people. These effects may be avoided or minimized by dividing up daily doses that are over 100 mg and taking them throughout the course of the day; for example, two or three times a day.
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