L-Arginine is a conditionally essential amino acid. This means that the body has the capability of manufacturing L-Arginine in the kidneys however, certain conditions sometimes disrupt this process. L-Arginine can then come from red meat, poultry, fish and dairy products. L-Arginine is largely and crucially involved in the synthesis of proteins. It is also known for influence on the vascular system and is the substrate for the nitric oxide synthase enzyme. There are many body functions and systems that rely on this conversion and the effects of nitric oxide, such as blood pressure, the cardiovascular system, the cells, etc. L-Arginine demonstrates detoxification and immunomodulatory activity as well.
L-Arginine has reported interactions with a variety of other drugs. L-Arginine should not be mingled with ace inhibitors (ACEIs), antihypertesive drugs, cyclosprine, nitrates, potassium-sparing diuretics, or slidenafil as the combinations may increate the risk of L-arginine induce hyperkalemia, additive hypotensive effects, additive vasodilation and may counteract the drug effects. When l-argnine is combined with estrogens or oral contraceptives, there may be an increase in the growth hormone response to arginine and a decrease in glucagon and insulin responses to arginine.
For the most part, l-arginine is well tolerated by most people when taken in the recommended dosage. At higher doses and for some people, l-arginine may cause nausea, abdominal pain, diarrhea, bloating, gout, a decrease in platelet count, and an increase in blood-urea-nitrogen (BUN). Allergic reactions may bring an inflammation of the airway, nasal blockage, increased pulse, choking, sweating, and redness.
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