Arginine

Arginine is involved in protein synthesis and is particularly known for influence on the vascular system. L-Arginine is converted by NOS (nitric oxide synthase) into nitric oxide, NO, the instigator of vasodilation. NOS is found in the brain, spinal cord, and peripheral system as eNOS. Arginine can increase the bioavailability of NO while decreasing the the levels of plasma endothelin-1 in circulation. L-Arginine is responsible for increased gastrin concentrations and tubular reabsorption of protein. Arginine also demonstrates some antioxidant abilities as well as anti-atherogenic activity and immunomodulatory activity. L-Arginine is considered a conditionally essential amino acid. This means that on average, the body can sufficiently produce adquate levels of arginine for the body however, under certain conditions this may not occur and supplementation would be necessary. Arginine is found naturally in red meat, poultry, fish, and dairy products.

Arginine may help to improve the results of ibuprofen. However, when combined with certain drugs, like ace inhibitors (ACEIs), antihypertensive drugs, cyclosporine, nitrates, slidenafils, and potassium-sparing diuretics, side effects such as hyperkalemia or decreased effectiveness of the drugs may occur as the arginine may counteract with the other ingredients. When arginine is combined with estrogens or oral contraceptives, there may be an increase in growth hormones, but a reduction in glucagon and insulin responses.

When L-Arginine is taken in the proper dosage, most people experience no difficulty with the supplement. However, if an over-dose occurs or side effects are felt, people typically experience nausea, abdomincal cramps, diarrhea, and bloating. In allergy cases or for those with asthma, an inflammation of the airway may occur. If you are allergic to l-arginine, you may have an increased pulse and sweating, feel flush and appear red, and experience nasal blockage.

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