Calcigard Two-to-One provides calcium and magnesium in a 2:1 ratio from the same sources. Calcigard tablets are formulated to disintegrate within 15 minutes or less following ingestion. Each batch of Calcigard Two-to-One is certified by independent laboratory assay to be free of lead and other toxic heavy metals.
Amni® Calcigard® One-to-One, provided by Douglas
Laboratories®, provides equal amounts of calcium as calcium
citrate, and magnesium as amino acid chelate, both with
excellent bioavailability. Calcigard™ Two-to-One provides
calcium and magnesium in a 2:1 ratio from the same sources.
Both formulas are available with and without added vitamin
D. Calcigard tablets are formulated to disintegrate within 15
minutes or less following ingestion. Each batch of Calcigard
One-to-One and Two-to-One is certified by independent
laboratory assay to be free of lead and other toxic heavy
The adult human body contains approximately 1,200 g of
calcium, of which about 99% is present in the skeleton, and
20-30 g of magnesium with about 60% located in bone. The
remaining 1% of total body calcium and 40% of total body
magnesium are found in the soft tissues and play important
roles in such vital functions as nerve conduction, muscle
contraction, energy metabolism, blood clotting, membrane
permeability, and hormonal signaling. Blood calcium levels
are carefully maintained within very narrow limits by the
interplay of several hormones (1,25-dihydroxycholecalciferol,
parathyroid hormone, calcitonin, estrogen,
and testosterone) which control calcium absorption and
excretion, as well as bone metabolism. The intracellular
levels of magnesium are also very tightly regulated, since
their alterations can have profound effects on cardiac and
skeletal muscle physiology.
Intestinal calcium absorption ranges from 15 to 75% of
ingested calcium. Adequate vitamin D status is necessary for
normal calcium absorption. Magnesium absorption is
independent of vitamin D status and ranges from 30 to 60%
of ingested magnesium.
Bone is constantly turning over, through a continuous
process of formation and resorption. In children and
adolescents, the rate of formation of bone mineral
predominates over the rate of resorption. In later life,
resorption predominates over formation. Therefore, in
normal aging, there is a gradual loss of bone.
Osteoporosis afflicts a large proportion of the elderly in
developed countries. Caucasian and Asian women typically
have low peak bone densities, and are therefore at the
greatest risk of developing osteoporosis. It is generally
accepted that obtaining enough dietary calcium throughout
life can significantly decrease the risk of developing
osteoporosis. Among other factors, such as regular exercise,
gender and race, calcium supplementation during childhood
and adolescence appears to be a prerequisite for maintaining
adequate bone density later in life. But even elderly
osteoporotic patients can benefit significantly from
supplementation with dietary calcium and magnesium.
Calcigard One-to-One and Two-to-One provide highly
beneficial sources of both calcium and magnesium. They are
well absorbed and well tolerated. Calcium citrate, a highly
bioavailable source of dietary calcium, is more completely
absorbed than common calcium sources, such as calcium
carbonate. Calcium citrate is also better tolerated than most
forms of calcium. It does not give rise to intestinal gas
production (due to release of carbon dioxide), bloating or
constipation as is often experienced with other calcium
preparations. Similarly, the magnesium amino acid chelate
in Calcigard One-to-One and Two-to-One is well absorbed
and generally well tolerated.
Vitamin D (optional ingredient) is a key regulatory hormone
for calcium and bone metabolism. Adequate vitamin D
intake is important for ensuring normal calcium absorption
and maintaining proper calcium plasma levels. People living
in southern regions of the U.S. can derive significant
amounts of vitamin D from sunlight dependent synthesis in
the skin during the summer, whereas people in the northern
states have to rely more on foods and supplements for
adequate vitamin D status. This is why Calcigard formulas
are available both with and without vitamin D.
modified cellulose gum,
Calcigard One-to-One: One to four tablets daily as a dietary
supplement, or as directed by a physician. Calcigard Twoto-
One: One to six tablets daily as a dietary supplement, or
as directed by a physician. Take with food. Individuals who
have trouble swallowing tablets may dissolve Calcigard
tablets in a glass of water or other suitable beverage.
corn, wheat, soya, sugar or other sweeteners, artificial flavors, colors or preservatives.
Calcigard One-to-One and Two-to-One are generally safe and well tolerated. Excessive dietary calcium, i.e., intakes of 2,000mg and more, may produce constipation and has no known further benefit to bone health. Excessive amounts of magnesium, such as 1,000 mg and more, may produce diarrhea.
Calcigard formulas should be used with caution by
individuals with hypercalcemia or serious renal