Calcium d-Glucarate 500mg 90 Capsules

By supplying a slow release form of D-glucaric acid, calcium D-glucarte is an effective agent that enhances the deactivation of toxic substances and encourages their elimination from the body. When calcium glucarate is converted to D-glucaro 1,4-lactone, it counteracts the enzyme beta-glucuronidase, which can otherwise interfere with conjugation and detoxification of steroid hormones and potentially carcinogenic compounds. Beta-glucuronidase enyzmes are present in all cells, particularly the liver, kidney, lung, intestinal epithelium, breast and endocrine organs. By inhibiting this enzyme, glucaric acid derivatives may exert a protective, non antioxidant effect on the immune system.

Amni® Calcium D-Glucarate, provided by Douglas

Laboratories®,. is a natural supplement of D-glucaric acid

bound to calcium.

Calcium D-glucarate enhances the body’s natural defenses

against environmental toxins and excess steroid hormones.

Through the actions of its metabolite D-glucaro-1,4-lactone,

calcium-d-glucarate indirectly favors glucuronidation, an

important system that the body relies upon to deactivate and

eliminate toxins and steroid hormones.

Glucuronidation is a conjugation process through which

potentially carcinogenic environmental toxins, such as

polycyclic aromatic hydrocarbons and nitrosamines, and

excess steroid hormones are neutralized. During

glucuronidation, the enzyme glucuronosyl transferase

catalyzes the conjugation of free carcinogens and steroid

hormones to glucuronic acid. The resulting glucuronidebound

toxins and hormones can then be safely excreted in

bile and urine.

The body also deconjugates glucuronide-bound end

products. The release of glucuronide-bound substances is

beneficial in some circumstances, for example, when the

excretion of steroid hormones is undesirable. Yet, the

deconjugation process, which works via the enzyme betaglucuronidase,

can result in the re-release of harmful toxins

back into the body.

The benefits of calcium D-glucarate are realized indirectly

through the action of its metabolite D-glucaro-1,4-lactone,

which inhibits the deconjugating enzyme beta-glucuronidase

found in both blood and tissue. Inhibition of beta-glucuronidase

causes a net increase in glucuronidation, and thereby enhances a

primary detoxification pathway in the body.

Animal studies have documented a decrease in B-glucuronidase

activity in breast, liver, colon, skin, lung, and prostate tissue

following oral administration of calcium D-glucarate.

Once ingested, calcium D-glucarate is converted to Dglucaric

acid in the presence of gastric HCl. The body

normally maintains an equilibrium between D-glucaric

acid and its two metabolites, D-glucaro-1,4-lactone and Dglucaro-Calcium D-glucarate provides a slow-release source of Dglucaro-

1,4-lactone. When taken directly, D-glucaro-1,4-

lactone is metabolized quite quickly and is excreted from

the body usually within 1-2 hours of its administration.

Calcium D-glucarate, however, is metabolized slowly,

remaining in the body for 5 or more hours after ingestion.

This results in maintenance of stable levels of D-glucaro-

1,4-lactone for long periods of time.

D-glucaric acid is produced endogenously in small amounts. It

is also present in some fruits and vegetables, including oranges,

apples, grapefruit, broccoli and other cruciferous vegetables.

6,3-lactone.

Supplement Facts