By supplying a slow release form of D-glucaric acid, calcium D-glucarte is an effective agent that enhances the deactivation of toxic substances and encourages their elimination from the body. When calcium glucarate is converted to D-glucaro 1,4-lactone, it counteracts the enzyme beta-glucuronidase, which can otherwise interfere with conjugation and detoxification of steroid hormones and potentially carcinogenic compounds. Beta-glucuronidase enyzmes are present in all cells, particularly the liver, kidney, lung, intestinal epithelium, breast and endocrine organs. By inhibiting this enzyme, glucaric acid derivatives may exert a protective, non antioxidant effect on the immune system.
Amni® Calcium D-Glucarate, provided by Douglas
Laboratories®,. is a natural supplement of D-glucaric acid
bound to calcium.
Calcium D-glucarate enhances the body’s natural defenses
against environmental toxins and excess steroid hormones.
Through the actions of its metabolite D-glucaro-1,4-lactone,
calcium-d-glucarate indirectly favors glucuronidation, an
important system that the body relies upon to deactivate and
eliminate toxins and steroid hormones.
Glucuronidation is a conjugation process through which
potentially carcinogenic environmental toxins, such as
polycyclic aromatic hydrocarbons and nitrosamines, and
excess steroid hormones are neutralized. During
glucuronidation, the enzyme glucuronosyl transferase
catalyzes the conjugation of free carcinogens and steroid
hormones to glucuronic acid. The resulting glucuronidebound
toxins and hormones can then be safely excreted in
bile and urine.
The body also deconjugates glucuronide-bound end
products. The release of glucuronide-bound substances is
beneficial in some circumstances, for example, when the
excretion of steroid hormones is undesirable. Yet, the
deconjugation process, which works via the enzyme betaglucuronidase,
can result in the re-release of harmful toxins
back into the body.
The benefits of calcium D-glucarate are realized indirectly
through the action of its metabolite D-glucaro-1,4-lactone,
which inhibits the deconjugating enzyme beta-glucuronidase
found in both blood and tissue. Inhibition of beta-glucuronidase
causes a net increase in glucuronidation, and thereby enhances a
primary detoxification pathway in the body.
Animal studies have documented a decrease in B-glucuronidase
activity in breast, liver, colon, skin, lung, and prostate tissue
following oral administration of calcium D-glucarate.
Once ingested, calcium D-glucarate is converted to Dglucaric
acid in the presence of gastric HCl. The body
normally maintains an equilibrium between D-glucaric
acid and its two metabolites, D-glucaro-1,4-lactone and Dglucaro-Calcium D-glucarate provides a slow-release source of Dglucaro-
1,4-lactone. When taken directly, D-glucaro-1,4-
lactone is metabolized quite quickly and is excreted from
the body usually within 1-2 hours of its administration.
Calcium D-glucarate, however, is metabolized slowly,
remaining in the body for 5 or more hours after ingestion.
This results in maintenance of stable levels of D-glucaro-
1,4-lactone for long periods of time.
D-glucaric acid is produced endogenously in small amounts. It
is also present in some fruits and vegetables, including oranges,
apples, grapefruit, broccoli and other cruciferous vegetables.
Gelatin, cellulose, water, and magnesium stearate.
One to two capsules daily as a dietary supplement, or as directed by physician.
Studies to date have not found toxic effects of calcium Dglucarate.
Human subjects in research trials of calcium Dglucarate
have not reported significant side effects.