Cogni-flex?, provided by Douglas Laboratories, is a unique
combination of nutrients and herbs (huperzine A, Ginkgo
biloba, phosphatidyl serine, and acetyl-L-carnitine) which
work in concert to maintain and enhance brain and nervous
system functions, including those involved in mental
alertness, clarity, and memory retention. These positive
effects of the four components of Cogni-flex? upon
structure and function of the nervous system are supported
by numerous scientific/clinical studies
The four nutrients in Cogni-flex? support the structure and
function of cognitive processes in several ways. They
support neurotransmitter metabolism, enhance vascular
circulation to the brain, and help maintain structure and
function of nerve cell membranes.
Huperzine A: An extract of the Chinese club moss,
Huperzia serrata, huperzine A has been used in Chinese
medicine for centuries. It is an effective inhibitor of
acetylcholinesterase, the enzyme that degrades acetylcholine,
the neurotransmitter important for normal memory and
learning function. Huperzine A may help maintain cognitive
function that has been degraded by a reduction in the brain’s
functional levels of the neurotransmitter acetylcholine.
Ginkgo biloba: Flavonoid compounds and terpene lactones
in the ginkgo leaf help regulate the structural tone and
elasticity of arteries and capillaries. As powerful antioxidants,
the ginkgo flavonoids counteract the deleterious actions of
free radical accumulation which impairs functional cellular
energy production and nerve transmission. Ginkgo biloba
extract is also reported to inhibit the tendency of red blood
cells to stick together (“clumping”), thereby enhancing the
functional fluidity of the blood. Improving the functional
circulation to the brain and other parts of the body allows for
better oxygen and glucose uptake, with subsequent
enhancement of memory and mental functions.
Phosphatidylserine: This phospholipid, found in high
concentrations in the nervous system, helps maintain
functional fluidity of nerve cell membranes, thus providing
for optimal transport of nutrients and other compounds across the cell membrane. It is also used in the repair and
regeneration of nerve cells. Phosphatidylserine also appears
to help the body counterbalance excessive release of
adrenocorticotropic hormone (ACTH), adrenaline, and
cortisol which are released in response to stress.
Acetyl-L-carnitine: This acetylated high energy ester of the
amino acid L-carnitine contributes its acetyl group to the
production of acetylcholine, the primary neurotransmitter for
memory and thought. The enzyme that makes acetylcholine
from acetyl groups and choline is choline acetyl transferase.
The activity of this important enzyme has a tendency to
decline with age, causing low acetylcholine levels which in
turn are thought to contribute to the impairment of brain
function that is associated with aging. Research has also
found that acetyl-L-carnitine is active in optimizing the
functioning of cerebral blood flow, as well as of nerve cell
Cogni-flex? capsules may be a useful dietary
supplement for those who wish to support the healthy
functioning of their mental processes.
Adults take 1 capsule daily or as directed by physician.
No significant side effects reported. Mild, transient
headaches may occur during the first 2-3 days of
taking Ginkgo biloba in people with previously insufficient cerebral blood flow, indicating the
activity of this herb. Ginkgo biloba may potentiate
the action of anticoagulants and central nervous
system drugs, as a result of its antithrombotic and
psychoactive functions, respectively.