Amni® Grapenol® tablets, provided by Douglas
Laboratories®, contain 100% pure, full-spectrum grape
extract. Each 50 mg scored tablet is formulated to
disintegrate rapidly within several minutes after ingestion for
This highly concentrated red grape extract (Vitis vinifera) is
specially prepared to retain the natural antioxidant and
biological activity of various nutritional compounds
occurring in the grape seeds, skin, and stems. Using the
whole grape, not just the seeds, yields a broader array of
antioxidant benefits, including those of resveratrol, a
powerful free radical fighter.
Proanthocyanidins (also called leukoanthocyanidins) are a
class of natural polyphenolic bioflavonoids that are very
widespread in nature. They are found in many herbs, fruits
and vegetables, and often are the main precursors of the
blue-violet and red pigments. More than 90% of the
proanthocyanidins in Grapenol occur as chains of two, three
or more proanthocyanidin molecules, which are called
oligomeric proanthocyanidins (OPC). These OPC are
considered most potent for their health benefits. Only a
small fraction of Grapenol proanthocyanidins are present as
single molecules (monomers, like catechin and epi-catechin).
Proanthocyanidins are highly regarded for their strong
antioxidant properties, and for their functions in supporting
the body’s connective tissues and capillary blood vessel
Europeans have been studying and using various forms of
these natural proanthocyanidins for several decades for their
numerous beneficial effects.
Proanthocyanidins are among the most powerful natural freeradical
scavengers yet discovered. As such,
proanthocyanidins have their own unique place in the body’s
overall protection against harmful free radical damage.
Proanthocyanidins appear to be especially effective in
neutralizing highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive oxygen species are involved
in inflammatory processes. Grapenol enhances the
effectiveness of vitamins C and E and can be taken together
with these vitamins for added benefit.
Proanthocyanidins also support and enhance the activity of
vitamin C, and are known for their ability to help support the
health of the body's capillary system and connective tissues.
Proanthocyanidins have been shown to bind with collagen
fibers, thereby protecting them from premature degradation.
This helps maintain the natural elasticity of collagen in skin,
joints, arteries, capillaries, and other connective tissues.
In addition to proanthocyanidins, Grapenol also contains
gallic acid and gallic acid esters, compounds that are known
for their astringent and antioxidant (gallic acid esters)
Grapenol full-spectrum grape extract, microcrystalline
cellulose, rice starch, silicon dioxide, and magnesium stearate.
The amount of Grapenol usually taken is based on body
weight as larger individuals can use more. Initial amounts
for the first 7 to 10 days range from 1.5 to 3.0 milligrams per
kilogram (2.2 pounds) of body weight, followed by
maintenance amounts of 50 to 100 mg per day (1 or 2
tablets) to replace what is lost daily.
yeast; corn; wheat; soya; sugar or other sweeteners, artificial
flavors, colors or preservatives.
None reported. Grapenol has been extensively tested over
many years to confirm its safety and purity. Grapenol is
reported to be non-toxic, non-mutagenic, non-teratogenic,
non-carcinogenic, and non-antigenic. Grapenol is quickly
absorbed and its proanthocyanidins can be detected in saliva
within one hour of ingestion. Absorbed amounts circulate in
body fluids and are held in collagen for 72 hours. It is
excreted primarily in the urine and secondarily through