Homocystrol tablets, provided by Douglas
Laboratories, contain significant amounts of vitamins
B-6, B-12, and folic acid, needed for proper
metabolism of homocysteine.
Homocysteinemia, or elevated plasma homocysteine,
is a major, independent risk factor of cardiovascular
disease. High plasma levels of homocysteine appear
to injure the vasculature, impairing the functional
abilities of endothelial and smooth muscle cells.
Elevated homocysteine also appears to be
thrombogenic. Suboptimal intake of several B
vitamins, renal failure, and genetic defects in
homocysteine metabolism can all contribute to
abnormal homocysteine levels.
Homocysteine is a sulfur containing amino acid that
is created in the body from methionine, an essential
amino acid derived solely from dietary intake.
Methionine is metabolized into homocysteine via an
intermediate, S-adenosylmethionine. Homocysteine
can be metabolized to produce cysteine, a nonessential
sulfur-containing amino acid, or it can be
remethylated to methionine. Whether the body needs
cysteine or methionine will dictate which path
homocysteine metabolism will take.
Production of cysteine from homocysteine requires
two specific enzymes for which vitamin B-6 is an
essential coenzyme. Without adequate vitamin B-6,
homocysteine can not be metabolized into cysteine.
The body can also metabolize homocysteine by
remethylating it to methionine. The primary route by
which homocysteine is remethylated to methionine
requires methyltetrahydrofolate as a methyl donor and
vitamin B-12 as a coenzyme. Methyltetrahydrofolate
is synthesized in the body from dietary folic acid.
Folic acid, vitamin B-12, and vitamin B-6 are
necessary for the body to metabolize homocysteine. A
deficiency or suboptimal levels any of these essential
vitamins will cause plasma homocysteine levels to rise.
Dietary surveys and epidemiological studies indicate
that suboptimal levels of folic acid, vitamin B-12, and
vitamin B-6 are common in many population groups.
Elderly individuals, smokers, alcoholics, and users of
many medications, including estrogens and popular
medications for cholesterol and blood glucose
control, are at risk for subclinical deficiencies of one
or more of these B vitamins.
Adults take 1 tablet daily or as directed by physician.
Let tablet dissolve in mouth.