Amni OcuTone, provided by Douglas Laboratories, is a
dietary supplement providing a well-balanced spectrum of
key nutrients that are important in maintaining normal eye
function. OcuTone delivers generous amounts of lutein,
beta-carotene, flavonoids, glutathione, sulfur-containing
amino acids, trace elements and a comprehensive array of
More than any other tissue in the body, the ocular lens and retina
are continually exposed to oxygen and intense light radiation.
Both light and oxygen can create free radicals that play havoc
with lipids in the membranes of visual cells. Experts believe that
the uncontrolled generation of free radicals in the eyes can
ultimately lead to macular degeneration and cataracts.
Therefore, ocular tissues rely on a strong antioxidant defense
system to protect them from free radical damage.
OcuTone was formulated to provide a comprehensive
combination of antioxidant nutrients that research has found
to be important for proper eye nutrition. OcuTone includes
nutritionally meaningful amounts of lutein, beta-carotene,
antioxidant vitamins, the trace elements zinc and selenium,
the cellular antioxidants glutathione and N-Acetyl-LCysteine,
the amino acid taurine, and potent flavonoids from
bilberries and grape seeds.
Lutein. Lutein is a carotenoid similar to beta-carotene. Recent
research has shown that lutein is the major eye pigment of the
outer retina. Lutein is especially concentrated in the rods,
which are the visual cells of the retina that are responsible for
black and white vision in the dark. The rods contain complex
membranes rich in polyunsaturated fatty acids that are
especially susceptible to lipid peroxidation and free radical
damage. Lutein is a potent antioxidant, and researchers
believe that the rods require it to protect themselves from lightinduced
Lutein occurs naturally in the diet, especially in dark green
leafy vegetables, broccoli and kale. Most people derive about
1 to 2 mg of lutein daily from their diets. Epidemiological
studies have shown that daily lutein intakes of 5 to 15 mg may
be more appropriate for maintaining normal eye function
during aging. As a result, OcuTone was formulated to provide
15 mg of natural lutein daily in three capsules.
Beta-Carotene. Beta-Carotene serves at least two purposes
for the eyes. It is a valuable precursor for vitamin A which
functions in the rod cells as a light receptor. Beta-Carotene
is also an important antioxidant in the lens and retina.
OcuTone delivers 12 mg of beta-carotene daily to ensure a
reliable supply of this important eye nutrient.
Vitamins C and E. The healthy ocular lens is rich in the
antioxidant vitamins C and E, which scavenge oxygen- and
light-induced free radicals. In the lens, excessive free
radicals can lead to protein oxidation and polymerization,
resulting in opaque, cloudy precipitates. High levels of
vitamins C and E, and other natural antioxidant defense
systems appear to be necessary for complete protection of
the delicate, highly transparent lens proteins. OcuTone
provides 500 mg of vitamin C and 400 I.U. of natural
vitamin E as d-alpha-tocopherol succinate.
Zinc. Zinc is essential for normal visual signal transduction
in the retina. Zinc is part of many of the enzymes involved
in vitamin A-dependent light reactions in the rod cells.
Moreover, zinc is an essential cofactor of superoxide
dismutase, an antioxidant enzyme that removes potentially
dangerous superoxide radicals in the visual cells, the lens,
and other tissues. OcuTone provides 6 mg of zinc in the
highly bioavailable monomethionine form.
Selenium. Selenium is the essential cofactor of the
antioxidant enzyme glutathione peroxidase, which is
abundant in healthy eyes. Glutathione peroxidase levels,
however, decline with advancing age, and experts believe
that adequate selenium nutrition can help maintain normal
production of this important enzyme. OcuTone provides
50 mcg of Selenium, which is roughly equivalent to the
required daily amount.
Glutathione and N-Acetyl-L-Cysteine. Glutathione is the
essential cosubstrate for glutathione peroxidase. To carry
out its antioxidant functions, this enzyme requires a steady
supply of glutathione. In addition, glutathione by itself
protects the proteins in the lens from becoming insoluble and
cloudy. Although well absorbed, dietary glutathione can not
enter the cell, and exerts much of its beneficial antioxidant
effects in the extracellular space. N-Acetyl-L-Cysteine
(NAC) easily enters the cell and is used to synthesize
intracellular glutathione. NAC also appears to have
antioxidant properties by itself.
Many studies have shown that ocular glutathione levels
decline as we age. Dietary supplementation with both
glutathione and NAC may help maintain normal extracellular
and intracellular glutathione levels. Therefore, OcuTone
combines a significant 50 mg of glutathione with 300 mg of
Taurine. Taurine, a conditionally-essential sulfur amino
acid, is the most abundant free amino acid in ocular tissues,
where it may function as a membrane stabilizer, antioxidant,
osmotic regulator, and neurotransmitter. Taurine is
important in maintaining normal extra- and intracellular
distribution of calcium. This in turn has implications for neuronal excitability and the regulation of osmotic pressure.
OcuTone provides 300 mg of pure taurine.
Bilberry Extract. Bilberries (Vaccinium myrtillus), a
northern European cousin of North American blueberries,
are a rich source of anthocyanosides, a class of flavonoids
recognized for their importance in eye health. Bilberry
anthocyanosides are potent antioxidants in the visual cells of
the retina, and help maintain normal blood flow in the fine
capillary blood vessels that nourish the eyes and other
tissues. Three capsules of OcuTone contain 60 mg of a
standardized 25 % anthocyanoside extract made from ripe
Grape Seed Extract. Grape seed extract is rich in
proanthocyanidins, another group of important flavonoids.
Proanthocyanidins are highly regarded for their strong antioxidant
properties and their role in supporting the body’s capillary blood
vessel system. Three capsules of OcuTone provide 50 mg of highquality
European grape seed extract (from Vitis vinifera) with a
minimum of 92 % proanthocyanidins.
Magnesium stearate, silicon dioxide, and cellulose.
Three capsules daily as a dietary supplement, or as directed
yeast; corn; wheat; soya; sugar or other sweeteners; artificial
flavors, colors or preservatives.
No adverse side effects have been reported. OcuTone and
each of its ingredients are very well tolerated. OcuTone may
be taken safely in conjunction with other supplements, such
as Basic Preventive® or Added Protection III®.