Prim Royal 60 Softgels

Prim Royal softgel capsules from Douglas

Laboratories contain 500 mg of oil of the evening

primrose herb (Oenothera biennis), providing 40 mg

of the nutritionally important gamma linolenic acid

(GLA) and 350 mg of the essential fatty acid, linoleic

acid.

Diets in developed countries are often rich in animal

products which deliver large amounts of saturated

fatty acids and the polyunsaturated arachidonic acid

(20:4 omega-6). Intakes of the essential linoleic acid

(18:2 omega-6) can be low in people who do not

regularly consume vegetable oils in their diets.

Arachidonic acid is a precursor for pro-inflammatory

immune mediators, the 2-series prostaglandins, e.g.

prostaglandin E2, the leukocyte chemotactic

metabolite, leukotriene B4, and platelet aggregating

thromboxane A2. Thromboxane A2 has been

implicated in the pathogenesis of coronary vascular

disease, as it is not only a potent platelet aggregator,

but also an effective vasoconstrictor.

Although gamma-linolenic acid (18:3 omega-6) is a

precursor of arachidonic acid, higher levels of dietary

GLA actually compete with arachidonic acid, and

may help downregulate the formation of excessive

levels of proinflammatory 2-series prostaglandins and

other immune mediators.

Dietary supplementation with GLA has been

suggested to be clinically effective in reducing the

signs and symptoms of immune dysfunction, e.g.

rheumatoid arthritis and lupus erythematosus. It has

also been clinically associated with improvement of

behavioral and physical problems, including

premenstrual syndrome, learning disability, mental

disturbance, weakness, poor coordination, and vision

impairment.

Recent studies suggest that dietary GLA can prevent

the deficit on sciatic nerve conduction velocity

(NCV) induced by diabetes. Although dietary GLA supplementation did not significantly influence the

fatty acid composition of nerve membrane

phospholipids, it was suggested that GLA’s effect

was due to its modulation of levels of vasodilatory

prostaglandins.

Evening primrose oil is recognized as an excellent

source of both GLA as well as the essential linoleic

acid. Therefore, regular supplementation with

evening primrose oil may be beneficial for people

consuming diets high in animal foods and low in

unprocessed vegetable oils.

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