Organic germanium is the common name given to biscarboxyethyl
germanium sesquioxide – a biologically active
compound of the element germanium containing carbon,
hydrogen and oxygen. Its chemical formula is
(GeCH2CH2COOH)2O3. This is the only form of germanium
that has been extensively studied for its health benefits.
What is Ge-132?
Ge-132 is the name given to organic germanium by the
Japanese chemist, Dr. K. Asai, who originally identified this
form of germanium in 1967. Today, the term Ge-132 is used
interchangeably with the name organic germanium to indicate
the compound bis-carboxyethyl germanium sesquioxide.
How safe is germanium?
Inorganic forms of germanium, such as germanium dioxide,
have been found to be quite toxic at high levels. However,
pure, organic germanium has no demonstrated toxicity, even
in very high amounts. The real safety issue concerning organic
germanium centers around its degree of purity. Improper
manufacturing procedures can result in impure organic
germanium. High quality organic germanium products have
a purity of 99.7% or greater.
How is the price of organic germanium related
to its quality?
Because organic germanium is expensive relative to most
other nutritional supplements, concerned customers fear that
low price may also mean low quality. Unfortunately, price is
no indication of germanium quality. While some high
quality products are fairly priced, others may be priced
excessively. Still others may be priced below the average
price of other germanium products even though they are of
equal high quality. Prices of lower quality germanium
products can vary just as much. The quality of available
germanium products should be evaluated based on objective
criteria which authenticate their purity. Once the quality is
established, a selection can easily be made on the basis of
preferred dosage form and competitive pricing.
What are the objective criteria that identify
pure, organic germanium?
It is the responsibility of the manufacturer to verify the
quality and purity of the organic germanium they provide.
This is accomplished only by performing appropriate quality control and analytical assay procedures. The following
testing protocol is used to establish the authenticity and
purity of organic germanium:
1) Appearance: Organic germanium is a white crystalline
powder that appears dense and free-flowing.
2) Solubility in Water: Pure organic germanium dissolves
in water leaving a clear, colorless solution with no evidence
of turbidity. This is tested by suspending a specified amount
of germanium sesquioxide (.20 gram) in 10 ml of deionized
water, agitating the suspension, and heating to 60° C at a rate
of approximately 5° per minute. Total solubility should occur
in less that 10 minutes. If either immediate solubility or prolonged
resistance to solubility occurs, foreign substances may be present.
3) Taste Evaluation: Pure organic germanium has a
characteristic slight acidic or astringent taste and dissolves
readily on the tongue. This test is valid only for the evaluation
of pure germanium powder. It is not appropriate for tablets,
capsules, or liquid formulations because of other ingredients
used during their manufacture.
4) Infrared Spectroscopy: An infrared spectrum is so
characteristic for a chemical compound that it is considered
to be its “fingerprint”. Organic germanium sesquioxide
shows well-defined infrared absorption bands at wave
numbers (cm-1) of 1690, 1410, 1240, 910 and 810. If any
defined absorption occurs at approximately 875 cm-1, the
undesirable germanium dioxide form may be present.
5) Loss on Drying: The moisture content of organic
germanium is a variable that must be considered as it helps
to determine the sesquioxide composition. Upon drying, the
weight loss of the material should be less than 0.5 percent,
otherwise, you may not be getting full value for your money
because of high water content.
6) Titration: This procedure measures the organic
germanium content of a material. A specified volume of
germanium sesquioxide solution is compared against
another solution of known concentration to determine the
purity of the germanium solution. A titration value of 99.7%
or greater indicates organic germanium with a high
degree of purity.
7) Elemental Germanium Content: The amount of elemental
germanium provided by the organic germanium compound is
another indicator of the purity of the material. Pure organic
germanium should contain 42.78% elemental germanium.
Given the inherent limitations of analytical instruments (Atomic
Absorption, ICP Emission Spectroscopy, etc.) used to measure
elemental germanium, the actual observed and acceptable range
is between 42.4 to 43.0 percent.
8) Elemental Nitrogen Content: Because some methods
for manufacturing germanium sesquioxide involve the use of
nitrogen-containing compounds, the nitrogen content can be
used as another indication of purity. If the material is of high
quality and purity, a negligible amount of nitrogen will be
9) Other Impurities: Because toxic heavy metals such as
lead and arsenic can occur as contaminants in a variety of
materials, the content of these should be determined to
ensure that safe and acceptable standards are not exceeded.
None of the above tests can be relied upon by itself to
establish germanium purity. Used together, they will
accurately confirm the quality of germanium sesquioxide.
Amni® uses all of the above indicators to ensure that only the
highest quality organic germanium material is provided in
Mannitol, stearic acid, magnesium stearate, and cellulose.
Take 1 tablet daily.