SAM-e Plus 30 Tablets

by Karuna

  • • 15 servings
$38.70

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Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and enhances neurotransmitter receptor affinity. SAM-e supports healthy joints both by increasing the number of articular chondrocytes, and by stimulating the synthesis of protective sulfated proteoglycans therein. SAM-e also protects synovial cells against pro-inflammatory prostanoids, and blocks enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions. SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.

Serving Size

2 Tablets, 15 servings per container

Other Ingredients

Calcium sulfate, stearic acid, silica, vegetable coating.

Suggested Use

Adults: Two to four tablets daily, preferably morning and evening, or as directed.

Supplement Facts

Serving Size is 2 Tablets
Amount Per Serving%DV
SAM-e (S-Adenosyl L-Methionine tosylate disulfate)400mg*
Choline (Bitartrate)50mg*
B3 (Niacinamide)30mg150%
B6 (pyridoxine HCl)2mg100%
Folic Acid400mcg100%
B12 (cyanocobalamin)20mcg333%
*Daily Value (DV) not established.


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