Folic Acid, Folate

Folic Acid, also referred to as folate or folacin in some forms, can be created by the body however, outside help is necessary to bond the vitamin together. Folic Acid is made up of three parts: pteridine, PABA, and glutamic acid, all three of which must be present for activity of the vitamin. Good food sources are mushrooms, green vegetables, legumes, and liver. Folic Acid is water-soluble member of the B Vitamin family. Folic Acid should be taken in proper quantities each day to ensure proper function of the body. Folic Acid is connected to the creation of THF as well as the metabolism of several amino acids and homocysteine. Homocysteine levels are maintained in part by folic acid as well. Folic Acid is closely tied to DNA, with the prevention of damage and replication errors. Folic Acid is a dynamic vitamin that displays antiatherogenic and anticarcinogenic qualities.

B6, B12, and folic acid may all work together to maintain homocysteine levels while zinc works against folic acid and the absorption of zinc is hindered. Methotrexate, aminosalicyclic acid, anatacids, antibiotics, aspirin, carbamazepine, cholestyramine, colestipol, cycloserine, estrogens, H2 blockers, metformin, methylprednisolone, and pancreatic extracts can hinder the absorption or reabsorption and function of folic acid in the body. Phenobarbital, phenytoin, and pyrimethamine are all effected negatively by the intake of folic acid and cannot fulfill their roles. Always consult with a health care professional before taking any type of medication or supplementation.

Folic is well tolerated by most people and for the most part, no side effects were reported by those taking up to 1000 mcg per day. Larger doses, around 5 mg per day, may cause abdominal cramps, diarrhea, and a rash. Folic Acid taken in 15 mg or more and for extensive periods of time, can cause altered sleep patterns, vivid dreaming, irritability, excitability, overactivity, confusion, impaired judgment, unusual behavior, nausea, abdomincal distention, flatulence, skin irritations, and zinc depletion. Allergic reactions may cause a rash, erythema, itching, malaise, and bronchospasm.

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