SAMe, or S-adenosyl-l-methionine, is an activated from of the essential amino acid methionine. SAMe is formed when ATP and methionine are combined. SAMe supports proper brain and liver function along with healthy connective tissues. SAMe plays an influential role in bone and joint strength. SAMe is present in most living cells and is not found abundantly in the diet, although methionine can beproduced by the body. WebVitamins has a selection of SAMe supplements to fit individual needs.